Central United States Vacations from $310

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Your Central United States Vacation

When it's time to set off on your next unforgettable adventure, a vacation package to Central United States is the answer. From this destination's friendly locals to all the other incredible things it's renowned for, there's a lot to discover. With so much to see and do on a trip to Central United States, it can be difficult to know where to begin. Kick off your travels in New York at Times Square and Central Park — two leading attractions here. Another great city worthy of a spot on your itinerary is Orlando. Don't miss Universal Studios Florida and Orlando International Premium Outlets. From the moment you book your Central United States vacation to when you return home, Expedia has your back every step of the way.

The Latest Central United States vacation packages

Price found within the past 48 hours. Click for updated prices.
The French Country Inn Lake Geneva
Tru by Hilton Alcoa Knoxville Airport
Quality Inn Oak Ridge
Comfort Suites Knoxville Airport
Holiday Inn Express & Suites Oak Ridge by IHG
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Where to stay in Central United States

Find the best Central United States areas and neighborhoods for the activities you enjoy most. Learn more about Central United States

Discover the most popular places to visit in Central United States

Central United States Hotel Deals

Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North

4 out of 5
600 N State St Chicago IL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $112 total per night from Nov 25 to Nov 26
$112 total
Nov 25 - Nov 26
Total with taxes and fees
8.4/10 Very Good! (5,235 reviews)
Clean room; kind and courteous staff; excellent breakfast and happy hour included

Reviewed on Nov 10, 2025

Embassy Suites by Hilton Chicago Downtown River North
Palmer House a Hilton Hotel

Palmer House a Hilton Hotel

4 out of 5
17 E Monroe St Chicago IL
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $149 total per night from Nov 24 to Nov 25
$149 total
Nov 24 - Nov 25
Total with taxes and fees
8.4/10 Very Good! (2,060 reviews)
Great location, great staff!

Reviewed on Nov 16, 2025

Palmer House a Hilton Hotel
Gaylord Opryland Resort & Convention Center

Gaylord Opryland Resort & Convention Center

4 out of 5
2800 Opryland Drive Nashville TN
Fully refundableReserve now, pay when you stay
$358 nightly
The price is $420 total per night from Dec 16 to Dec 17
$420 total
Dec 16 - Dec 17
Total with taxes and fees
8.6/10 Excellent! (1,736 reviews)
The room was very clean. and cleaned everyday. We missed having a microwave. The bed and pillows very comfee

Reviewed on Nov 13, 2025

Gaylord Opryland Resort & Convention Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Central United States Vacation Packages

Central United States Essential Information

Language
English
Currency
U.S dollars
Closest Airport
O'Hare Intl. Airport (ORD)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.